Microsoft unveils CLIO to give scientists control over AI reasoning
Microsoft just introduced CLIO, a runtime optimization framework that enables base LLMs to self-adapt their reasoning without reinforcement learning post-training. On Humanity's Last Exam biology and medicine questions, it pushed GPT-4.1's accuracy from 8.55% to 22.37%, outperforming OpenAI's o3. Why it matters: scientists get real control knobs to flag uncertainty and correct thought paths mid-stream.